CCM Care Guidelines – 2025 Update

These guidelines benefit the patient and clinical communities by providing a comprehensive set of consensus guidelines for CCM diagnosis, monitoring, and treatment. The authors include members of the Alliance to Cure Cavernous Malformation Scientific and Medical Advisory Boards and invited experts.

This 2025 update of the 2017 guidelines offers the latest information on lifestyle factors impacting hemorrhage, expanded spinal cavernous malformation and pediatric CCM sections, and diagnostic guidelines.

The Guidelines and supplementary materials are available online in the journal Neurosurgery as of May 21, 2025, where they may be downloaded and shared.

You can also find them on our website:

Guidelines for the Diagnosis and Clinical Management of Cerebral Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on Systematic Literature Review By the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel – 2025 Update

With Supplemental Materials:

Guidelines for the Diagnosis and Clinical Management of Cerebral Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on Systematic Literature Review By the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel – 2025 Update – Supplemental Material

Updated 5.21.2025