What role does vitamin D play in cavernous malformation?
We know that inflammation is one of the mechanisms that drive cavernous malformation disease. Vitamin D is a natural anti-inflammatory and is beneficial to the immune system because it helps the body combat oxidative stress.
Research has shown a correlation between a more aggressive course of cavernous malformation and low vitamin D levels. There is also speculation that a cause of symptom exacerbation during the winter months is due to sub-optimal vitamin D levels.
How much vitamin D is recommended?
It is recommended to test your blood serum levels of 25(OH)D and supplement accordingly with D3 (cholecalciferol) under the guidance of your practitioner.
The best way to obtain vitamin D is by going out in the sun and absorbing it through the skin. The amount of vitamin D that is absorbed depends on your location, time of year, and time of day, but during warmer months benefits can be achieved in just ten minutes of midday exposure daily.
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Flemming K, D, Kumar S, Brown Jr R, D, Singh R, J, Whitehead K, McCreath L, Lanzino G: Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level. Cerebrovasc Dis 2020;49:216-222.
Awad IA, Polster SP. cavernous malformations: deconstructing a neurosurgical disease. J Neurosurg. July 2019;131(1):1–13.
Lyne SB, Girard R, Koskimäki J, et al. Biomarkers of cavernous malformation with symptomatic hemorrhage. JCI Insight. 2019;4(12):e128577. Published 2019 Jun 20.