We know individuals with cavernous malformation experience more frequent headaches than others. It is the most-reported symptom by those with cavernous malformation. A headache does not necessarily mean a new hemorrhage.

For the most part, we cannot distinguish a cavernous malformation headache from any other kind of headache. A headache unlike one you have ever experienced or headaches, particularly on the same side or general location as your lesion, may be related to your lesion. Lesions located deeper within the brain, with or without hemorrhage, are less likely to cause headaches. Any changes in your neurologic status or shift from your typical headaches should be brought to your doctor’s attention.

There are several types of very painful headache that are not related to cavernous malformation hemorrhage. These will need to be ruled out before concluding that your headache is the result of your cavernous malformation.


Migraines typically present with severe throbbing pain on one-side of the head and is often accompanied by nausea, vomiting, cold hands, and sensitivity to sound and light. Your migraine may be associated with or without aura (a warning sign typically with visual disturbances). Migraines are considered chronic if they occur more than fifteen days a month, for more than three months, that have the features of migraine headache on at least eight days per month. The standard treatment of migraine is safely recommended for patients with CCM.

Cluster Headache

These types of headaches can be very painful and come on very quickly, typically during sleep. They usually occur around or behind the eye and may be accompanied by other symptoms including tearing of the eye and congestion. These attacks will occur every day for as long as weeks or months and then go into a remission period.

woman with headache
Giant Temporal Arteritis

Giant temporal arteritis is rarely experienced in cavernous malformation patients, but it can cause inflammation in the temporal arteries triggering piercing headaches. The pain is usually felt around the ear and can present with jaw pain and loss of vision that may be temporary or permanent.

Rebound Headache

Rebound headaches occur because of regular, chronic medication use to treat headaches. This cycle will cause headaches to return once your medication wears off. Symptoms of rebound headaches can happen as often as every day, usually first thing in the morning, and may feel different than the headache you were treating. It is important to monitor your headaches for any changes and work with a provider on finding the cause and the best course of treatment.

Headache Treatment

Acetaminophen (Tylenol)

This is the typical treatment for most types of headaches as there is no risk of hemorrhage.

Nonsteroidal anti-inflammatories (NSAIDs)

NSAIDs are a family of over the counter medications that include ibuprofen and aspirin. These are generally avoided by most patients with cavernous malformation due to their blood-thinning properties. However, new evidence indicates that their use does not provoke hemorrhage. Until we know more, it is not advisable to start using blood thinners without consulting a practitioner well-versed in CCM. Please visit our page on blood thinners for more information.


There are several different Triptan medications available for the treatment of migraine. Triptans act on the serotonin receptors and also on the tiny muscles that surround the small arteries in the brain causing them to go into a spasm. That spasm can increase the risk of brain bleeds in general, not specifically pertaining to cavernous malformation bleeds. Due to the association of cerebral hemorrhages in general with Triptan medications, there is reservation in the use of these medications with cavernous malformation patients.  While there is no research linking triptans to an increase in cavernous malformation hemorrhage, because of its history with general brain bleeds, it is often avoided.

CGRP Inhibitors

Calcitonin gene-related peptide (CGRP) inhibitors block the effect of CGRP, which is a small protein that is highly prevalent in the sensory nerves that supply the head and the neck. CGRP is involved in pain transmission and levels increase during a migraine. It may also play a causative role in the induction of migraine attacks. CGRP inhibitor medications are used to manage migraines.


Botox is approved for the use of chronic migraine and may be offered as a treatment. While the safety of using Botox if you have a cavernous malformation is unknown, a 2020 paper provided details of a case study of an individual who experienced two symptomatic hemorrhages following high doses of Botox. Until more is understood in this area, it is recommended to explore all your treatment options for headaches with a practitioner who is well-versed in CCM.

Tips for preventing headache

  • Identify and avoid dietary triggers. Keeping a journal is a great way to track this.
  • Consume a healthy diet that avoids processed foods
  • Ensure good sleep hygiene
  • Maintain a healthy blood pressure
  • Avoid stress and try relaxation techniques
  • Engage in regular movement
  • Avoid excess use of alcohol and caffeine
  • Stay hydrated

This chart from the National Headache Foundation details the different types of headaches one can experience. Additionally, they offer information on treatment, prevention and a listing of qualified specialists who treat headaches.

For a Comprehensive Look at Treating Headaches in the Cavernous Malformation Population Watch Dr. Tarun Girotra’s Headaches and Pain Management Webinar.

Updated 6.12.2023


  • Koskimäki J, Zhang D, Carrión-Penagos J, et al. Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature. World Neurosurg. 2020;136:7-11.
  • Zuurbier, Susanna M et al. Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis. The Lancet Neurology. 2019;18(10):935-941.
  • Akers A, et al. Synopsis of guidelines for the clinical management of cerebral cavernous malformations: consensus recommendations based on systematic literature review by the Alliance to Cure Cavernous Malformation Scientific Advisory Board Clinical Experts Panel. Neurosurgery. 2017;80(5):665–680.